Unleashing the Power of Deep Attention Networks: A Comprehensive Approach for Enhanced Artificial Intelligence

Deep learning has revolutionized the field of artificial intelligence by achieving state-of-the-art performance on a variety of complex tasks. Attention mechanisms have emerged as a powerful tool to enhance the capabilities of deep neural networks by enabling them to selectively focus on relevant information. In this article, we propose a novel artificial intelligence algorithm called Deep Attention Networks (DANs), which associate multiple attention mechanisms to improve performance on interesting tasks. We evaluate DANs on benchmark datasets in natural language processing, computer vision, and speech recognition and demonstrate superior results compared to existing state-of-the-art approaches. Our approach opens up new possibilities for advancing the field of artificial intelligence and holds promise for various real-world applications. Overall, our results demonstrate the effectiveness and potential of DANs for various AI applications, and highlight the power of combining deep neural networks with attention mechanisms

Simultaneous measurement of Ca2+ release and influx into smooth muscle cells in response to caffeine. A novel approach for calculating the fraction of current carried by calcium

Activation of ryanodine receptors on the sarcoplasmic reticulum of single smooth muscle cells from the stomach muscularis of Bufo marinus by caffeine is accompanied by a rise in cytoplasmic [Ca2+] ([Ca2+]i), and the opening of nonselective cationic plasma membrane channels. To understand how each of these pathways contributes to the rise in [Ca2+]i, one needs to separately monitor Ca2+ entry through them. Such information was obtained from simultaneous measurements of ionic currents and [Ca2+]i by the development of a novel and general method to assess the fraction of current induced by an agonist that is carried by Ca2+. Application of this method to the currents induced in these smooth muscle cells by caffeine revealed that approximately 20% of the current passing through the membrane channels activated following caffeine application is carried by Ca2+. Based on this information we found that while Ca2+ entry through these channels rises slowly, release of Ca2+ from stores, while starting at the same time, is much faster and briefer. Detailed quantitative analysis of the Ca2+ release from stores suggests that it most likely decays due to depletion of Ca2+ in those stores. When caffeine was applied twice to a cell with only a brief (30 s) interval in between, the amount of Ca2+ released from stores was markedly diminished following the second caffeine application whereas the current carried in part by Ca2+ entry across the plasma membrane was not significantly affected. These and other studies described in the preceding paper indicate that activation of the nonselective cation plasma membrane channels in response to caffeine was not caused as a consequence of emptying of internal Ca2+ stores. Rather, it is proposed that caffeine activates these membrane channels either by direct interaction or alternatively by a linkage between ryanodine receptors on the sarcoplasmic reticulum and the nonselective cation channels on the surface membrane

Caffeine activates a Ca(2+)-permeable, nonselective cation channel in smooth muscle cells

The effects of caffeine on cytoplasmic [Ca2+] ([Ca2+]i) and plasma membrane currents were studied in single gastric smooth muscle cells dissociated from the toad, Bufo marinus. Experiments were carried out using Fura-2 for measuring [Ca2+]i and tight-seal voltage-clamp techniques for recording membrane currents. When the membrane potential was held at -80 mV, in 15% of the cells studied caffeine increased [Ca2+]i without having any effect on membrane currents. In these cells ryanodine completely abolished any caffeine induced increase in [Ca2+]i. In the other cells caffeine caused both an increase in [Ca2+]i and activation of an 80-pS nonselective cation channel. In this group of cells ryanodine only partially blocked the increase in [Ca2+]i induced by caffeine; moreover, the change in [Ca2+]i that did occur was tightly coupled to the time course and magnitude of the cation current through these channels. In the presence of ryanodine, blockade of the 80-pS channel by GdCl3 or decreasing the driving force for Ca2+ influx through the plasma membrane by holding the membrane potential at +60 mV almost completely blocked the increase in [Ca2+]i induced by caffeine. Thus, the channel activated by caffeine appears to be permeable to Ca2+. Caffeine activated the cation channel even when [Ca2+]i was clamped to below 10 nM when the patch pipette contained 10 mM BAPTA suggesting that caffeine directly activates the channel and that it is not being activated by the increase in Ca2+ that occurs when caffeine is applied to the cell. Corroborating this suggestion were additional results showing that when the membrane was depolarized to activate voltage-gated Ca2+ channels or when Ca2+ was released from carbachol-sensitive internal Ca2+ stores, the 80-pS channel was not activated. Moreover, caffeine was able to activate the channel in the presence of ryanodine at both positive and negative potentials, both conditions preventing release of Ca2+ from stores and the former preventing its influx. In summary, in gastric smooth muscle cells caffeine transiently releases Ca2+ from a ryanodine-sensitive internal store and also increases Ca2+ influx through the plasma membrane by activating an 80-pS cation channel by a mechanism which does not seem to involve an elevation of [Ca2+]i

Identifikasi Keragaman Morfologi Daun Mangga (Mangifera Indica L.) Pada Tanaman Hasil Persilangan Antara Varietas Arumanis 143 Dengan Podang Urang Umur 2 Tahun

Buah mangga (Mangifera indica L.) merupakan tanaman buah yang potensial dikembangkan karena mempunyai tingkat keragaman genetik yang tinggi. Variasi yang cukup tinggi pada bentuk, ukuran dan warna daun mangga menunjukkan adanya keragaman genetik yang cukup luas. Tujuan dari penelitian ini adalah untuk mengetahui keragaman morfologi daun mangga sehingga dapat digunakan sebagai salah satu cara mendeteksi dini keragaman morfologi daun hasil persilangan antara mangga varietas Arumanis 143 dengan Podang Urang. Pengamatan dilakukan pada bagian daun, mulai flush daun sampai daun menjadi sempurna dan berwarna hijau tua. Pengamatan tanaman sampel dilakukan dengan 2 metode, metode non-destruktif yang terdiri dari pengamatan warna daun, warna tulang daun, panjang daun, lebar daun, rasio P/L daun dan lama perkembangan daun, sedangkan untuk metode destruktif terdiri dari pengamatan jumlah daun per flush, posisi duduk daun pada batang, bangun atau bentuk daun dan luas daun maksimum. Data akan dianalisis dengan menggunakan Hierarkhi Cluster metode Average Linkage (Between Groups) program SPSS 13 dan hasilnya disajikan dalam bentuk Dendrogram. Hasil penelitian menunjukkan bahwa dari hasil pengamatan metode kualitatif maupun kuantitatif yang dilanjutkan dengan metode cluster pada daun mangga diperoleh 2 cluster. Cluster 1 yaitu klon yang memiliki hubungan kekerabatan yang dekat dengan kedua tetuanya, 32 klon. Sedangakan cluster 2 merupakan klon harapan dari hasil persilangan Arumanis 143 dan Podang Urang, 12 klon

Effect of experimental laser imperfections on laser wakefield acceleration and betatron source

International audienceLaser pulses in current ultra-short TW systems are far from being ideal Gaussian beams. The influence of the presence of non-Gaussian features of the laser pulse is investigated here from experiments and 3D Particle-in-Cell simulations. Both the experimental intensity distribution and wavefront are used as input in the simulations. It is shown that a quantitative agreement between experimental data and simulations requires to use realistic pulse features. Moreover, some trends found in the experiments, such as the growing of the X-ray signal with the plasma length, can only be retrieved in simulations with realistic pulses. The performances on the electron acceleration and the synchrotron X-ray emission are strongly degraded by these non-Gaussian features, even keeping constant the total laser energy. A drop on the X-ray photon number by one order of magnitude was found. This clearly put forward the limitation of using a Gaussian beam in the simulations

Investigating the functionality of an OCT4-short response element in human induced pluripotent stem cells.

Pluripotent stem cells offer great therapeutic promise for personalized treatment platforms for numerous injuries, disorders, and diseases. Octamer-binding transcription factor 4 (OCT4) is a key regulatory gene maintaining pluripotency and self-renewal of mammalian cells. With site-specific integration for gene correction in cellular therapeutics, use of the OCT4 promoter may have advantages when expressing a suicide gene if pluripotency remains. However, the human OCT4 promoter region is 4 kb in size, limiting the capacity of therapeutic genes and other regulatory components for viral vectors, and decreasing the efficiency of homologous recombination. The purpose of this investigation was to characterize the functionality of a novel 967bp OCT4-short response element during pluripotency and to examine the OCT4 titer-dependent response during differentiation to human derivatives not expressing OCT4. Our findings demonstrate that the OCT4-short response element is active in pluripotency and this activity is in high correlation with transgene expression in vitro, and the OCT4-short response element is inactivated when pluripotent cells differentiate. These studies demonstrate that this shortened OCT4 regulatory element is functional and may be useful as part of an optimized safety component in a site-specific gene transferring system that could be used as an efficient and clinically applicable safety platform for gene transfer in cellular therapeutics

Heat exchange between two interacting nanoparticles beyond the fluctuation-dissipation regime

We show that the observed non-monotonic behavior of the thermal conductance between two nanoparticles when they are brought into contact is originated by an intricate phase space dynamics. Here it is assumed that this dynamics results from the thermally activated jumping through a rough energy landscape. A hierarchy of relaxation times plays the key role in the description of this complex phase space behaviour. Our theory enables us to analyze the heat transfer just before and at the moment of contact.Comment: 4 pages, 1 figure, approved for publication in Physical Review Letter

Asymptotic Behavior of the Correlator for Polyakov Loops

The asymptotic behavior of the correlator for Polyakov loop operators separated by a large distance $R$ is determined for high temperature QCD. It is dominated by nonperturbative effects related to the exchange of magnetostatic gluons. To analyze the asymptotic behavior, the problem is formulated in terms of the effective field theory of QCD in 3 space dimensions. The Polyakov loop operator is expanded in terms of local gauge-invariant operators constructed out of the magnetostatic gauge field, with coefficients that can be calculated using resummed perturbation theory. The asymptotic behavior of the correlator is $\exp(-MR)/R$, where $M$ is the mass of the lowest-lying glueball in $(2+1)$-dimensional QCD. This result implies that existing lattice calculations of the Polyakov loop correlator at the highest temperatures available do not probe the true asymptotic region in $R$.Comment: 10 pages, NUHEP-TH-94-2

‘It’s better than daytime television’: questioning the socio-spatial impacts of massage parlours on residential communities

It has been shown that street sex work is problematic for some communities, but there is less evidence of the effects of brothels. Emerging research also suggests that impact discourses outlined by residential communities and in regulatory policies should be critiqued, because they are often based on minority community voices, and limited tangible evidence is used to masquerade wider moral viewpoints about the place of sex work. Using a study of residents living in close proximity to brothels in Blackpool, this paper argues that impact is socially and spatially fluid. Impact needs to be evaluated in a more nuanced manner, which is considerate of the heterogeneity of (even one type of) sex work, and the community in question. Brothels in Blackpool had a variety of roles in the everyday socio-spatial fabric; thus also questioning the common assumption that sex work only impacts negatively on residential communities

Effective Field Theory Approach to High-Temperature Thermodynamics

An effective field theory approach is developed for calculating the thermodynamic properties of a field theory at high temperature $T$ and weak coupling $g$. The effective theory is the 3-dimensional field theory obtained by dimensional reduction to the bosonic zero-frequency modes. The parameters of the effective theory can be calculated as perturbation series in the running coupling constant $g^2(T)$. The free energy is separated into the contributions from the momentum scales $T$ and $gT$, respectively. The first term can be written as a perturbation series in $g^2(T)$. If all forces are screened at the scale $gT$, the second term can be calculated as a perturbation series in $g(T)$ beginning at order $g^3$. The parameters of the effective theory satisfy renormalization group equations that can be used to sum up leading logarithms of $T/(gT)$. We apply this method to a massless scalar field with a $\Phi^4$ interaction, calculating the free energy to order $g^6 \log g$ and the screening mass to order $g^5 \log g$.Comment: 40 pages, LaTeX, 5 uuecoded figure